- Product Details
Keywords
- 152121-30-7 supplier
- SB202190
- p38,MAPK,inhibitor
Quick Details
- ProName: SB202190
- CasNo: 152121-30-7
- Molecular Formula: C20H14FN3O
- Appearance: light Yellow solid
- Application: for research
- DeliveryTime: 1 week
- PackAge: foil bag
- Port: shanghai\Tianjin
- ProductionCapacity: 10 Kilogram/Month
- Purity: 99%
- Storage: Keep away from fire and heat source;ke...
- Transportation: DHL\TNT\FEDEX...
- LimitNum: 1 Gram
- 分子量: 152121-30-7
Superiority
SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase,SB202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively).
Details
SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase,SB202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively).
[1]. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase.inhibitors. Biochem.J. 351 95.
[2]. Karahashi H et al A selective inhibitor of p38 MAP kinase, SB202190, induced apoptotic cell death of a lipopolysaccharide-treated macrophage-like cell line, J774.1 Biochim Biophys Acta. 2000 Oct 18;1502(2):207-23.
[3]. Winnicki K, Maszewski J.SB202190 affects cell response to hydroxyurea-induced genotoxic tress in root meristems of Vicia faba.Plant Physiol Biochem. 2012 Aug 13;60C:129-136.
[4]. Keshari RS, Verma A, Barthwal MK, Dikshit M.Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA- induced NETs release from human neutrophils.J Cell Biochem.2012 Sep 7.
[5]. Zbinden-Foncea H, Deldicque L, Pierre N, Francaux M, Raymackers JM.TLR2 and TLR4 activation induces p38 MAPK-dependent phosphorylation..